12
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4517 | L189 | DNA , DNA/RNA Synthesis | |
L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM). | |||
T3103 | L67 | DNA Ligase Inhibitor | DNA , DNA/RNA Synthesis |
L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM). | |||
T1724 | SCR7 pyrazine | SCR7 | Apoptosis , DNA/RNA Synthesis , CRISPR/Cas9 |
SCR7 pyrazine (SCR7) enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ). | |||
T9150 | SCR130 | 1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- | Apoptosis , Others , DNA/RNA Synthesis |
SCR130 (1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-) is enzyme inhibition, antiproliferative effects and antifungal activity. | |||
T6611 | NSC697923 | 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran | E1/E2/E3 Enzyme |
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct me... | |||
T3340 | SCR7 | Apoptosis , DNA/RNA Synthesis , CRISPR/Cas9 | |
SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ). | |||
T6407 | β-Lapachone | Beta-Lapachone,NSC-26326,SL-11001,ARQ-501 | IDO , Apoptosis , Topoisomerase , Autophagy |
β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase. | |||
T60753 | L82 | DNA | |
L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells. | |||
T36733 | HLI373 dihydrochloride | ||
HLI373 dihydrochloride is a potent Hdm2 inhibitor, efficiently restraining the ubiquitin ligase activity of Hdm2 and effectively prompting apoptosis in DNA-damaging agent-sensitive tumor cells[1]. Additionally, HLI373 di... | |||
T78166 | MEL24 | Others | |
MEL24, an Mdm2 E3 ligase inhibitor, diminishes cell viability and enhances sensitivity to DNA-damaging agents in a p53-dependent manner, suggesting its potential for in vitro antitumor research [1]. | |||
T22087 | HLI 373 | ||
HLI373 is an efficacious Hdm2 inhibitor. Hdm2 is an ubiquitin ligase (E3). HLI373 is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents [1]. HLI 373 also shows prominent anti... | |||
T69117 | Pinafide | ||
Pinafide is a rodenticide and anti-protozoal agent. Pinafide shows strong cytostatic activity against both HeLa and KB cells and is moderately toxic to both mice and rats. It has been proved active against experimental t... |